Journal: iScience
Article Title: Trajectories of macrophage ontogeny and reprogramming in cancer
doi: 10.1016/j.isci.2025.112498
Figure Lengend Snippet: D KO enhances tumor response to antiangiogenic immunotherapy (A) Schematic of the experimental setup. (B) Volume of individual lung tumors (mean ± SEM) in mice treated as indicated and imaged by micro-CT at day 28 post-tumor injection. n=6 D WT mice treated with IgG1+IgG2a (WT IgGs); n=7 D WT mice treated with A2V+α-PD1 (WT A2V+α-PD1); n=5 D KO mice (KO IgGs and KO A2V+α-PD1). Note that each mouse carries several independent lung tumors. Statistical analysis by unpaired Student’s t test performed between control and interventional treatment for each independent genotype. ∗ p ≤ 0.05.
Article Snippet: For the latter study, irrelevant control IgGs were a combination of IgG1 (20 mg/kg; clone MOPC-21, Roche) and rat IgG2a (10 mg/kg; clone 2A3, BE0089, Bio X Cell).
Techniques: Micro-CT, Injection, Control